Antituberculosis treAtment-induced HepAtotoxicity: From bencH to bedside

نویسندگان

  • SK Sharma
  • Alladi Mohan
چکیده

commonly encountered adverse effect withantituberculosis treatment.6-8 Recent developments especially in the field of molecular biology have expanded our views on the understanding of drug-induced liver damage. 9,10 In this paper, we have attempted to summarise the current understanding of the pathogenetic mechanismsof DIH as it has been viewed from the laboratory bench and the bedsideimplications of these observations to the practicingclinician with particular reference toantituberculosis drugs. MEcHAnISMS oF druG‐InducEd

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

تعیین عوامل موثر بر مسمومیت کبدی ناشی از درمان ضد سل ریوی

ABSTRACT Hepatotoxicity is a severe side effect of antituberculosis therapy.In litrature review approximatly10-20% of adults treated with the antituberculosis agents,elevated serum aminotransferase and 1% at them develop to hepatitis.The aim of this study is determinat...

متن کامل

Antituberculosis Drug-Induced Hepatotoxicity in Iranian Tuberculosis Patients: Role of Isoniazid Metabolic Polymorphism

The aim of this study was to determine the association of n-acetyltransferase-2 polymorphisms and anti-tuberculosis drug-induced hepatotoxicity in Iranian pulmonary tuberculosis patients. Acetylating phenotypes was studied in 50 Iranian pulmonary tuberculosis patients using metabolic ratio of plasma acetyl-Isoniazid to Isoniazid. The association between hepatotoxicity and the n-acetyltransferas...

متن کامل

Antituberculosis Drug-Induced Hepatotoxicity in Iranian Tuberculosis Patients: Role of Isoniazid Metabolic Polymorphism

The aim of this study was to determine the association of n-acetyltransferase-2 polymorphisms and anti-tuberculosis drug-induced hepatotoxicity in Iranian pulmonary tuberculosis patients. Acetylating phenotypes was studied in 50 Iranian pulmonary tuberculosis patients using metabolic ratio of plasma acetyl-Isoniazid to Isoniazid. The association between hepatotoxicity and the n-acetyltransferas...

متن کامل

ارزیابی آسیب کبدی ناشی از مصرف دارو و ارتباط آن با پلی مرفیسم های ژن NAT2 در بیماران مبتلا به سل

Background and purpose: The main purpose of this study was determination of different genotypes and phenotypes of N-acetyltransferase 2 gene and its relationship with drug-induced liver injury among patients in Mazandaran province, Iran, which was done for the first time. Materials and methods: A total of 65 newly diagnosed unrelated pulmonary tuberculosis patients (47 men, 18 women) was enrol...

متن کامل

Antituberculosis drug-induced hepatotoxicity: a comparison between patients with and without human immunodeficiency virus seropositivity.

INTRODUCTION The prevalence and risk factors for rifampin, isoniazid and pyrazinamide hepatotoxicity were evaluated in HIV-infected subjects and controls. METHODS Patients with tuberculosis (30 HIV positive and 132 HIV negative), aged between 18 and 80 years-old, admitted to hospital in Brazil, from 2005 to 2007, were selected for this investigation. Three definitions of hepatotoxicity were u...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2009